Nuclear singlet multimers (NUSIMERs) with long-lived singlet states.

ABSTRACT: Magnetic resonance (NMR) is a powerful tool in chemical analysis, structure determination and in medical diagnostics. Developing novel biological sensors for this field holds promise to better investigate protein structures or target diseases more efficiently. Herein, we explore nuclear spin singlet states in dendritic macromolecules as a platform molecule to develop stimuli responsive probes. We have developed a nuclear singlet multimer (NUSIMER) based on a generation 5 poly(amidoamine) dendrimer (PAMAM) which contains on average about 90 accessible nuclear spin singlet states with lifetimes up to 10-fold longer than the T ₁ relaxation times (up to 10 seconds T _s vs. T ₁ < 0.5 seconds) in a single molecule. We demonstrate little influe

SUBMITTER: Saul P 

PROVIDER: S-EPMC6334717 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature