Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis.

ABSTRACT: Mitochondria originated from proteobacterial endosymbionts, and their transition to organelles was tightly linked to establishment of the protein import pathways. The initial import of most proteins is mediated by the translocase of the outer membrane (TOM). Although TOM is common to all forms of mitochondria, an unexpected diversity of subunits between eukaryotic lineages has been predicted. However, experimental knowledge is limited to a few organisms, and so far, it remains unsettled whether the triplet-pore or the twin-pore structure is the generic form of TOM complex. Here, we analysed the TOM complex in hydrogenosomes, a metabolically specialised anaerobic form of mitochondria found in the excavate Trichomonas vaginalis. We demonstrate that the highly divergent β-barrel T. vaginalis

SUBMITTER: Makki A 

PROVIDER: S-EPMC6334971 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature