Treatment of hypercholesterolaemia with PCSK9 inhibitors in patients after cardiac transplantation.

ABSTRACT:

Background

Hypercholesterolaemia is common in patients after cardiac transplantation. Monoclonal antibodies that inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9) reduce low-density lipoprotein (LDL) cholesterol levels and subsequently the risk of cardiovascular events in patients with dyslipidaemia. There are no published data on the effect of this medication class on cholesterol levels in patients after cardiac transplantation.

Methods

In this retrospective study we investigated patients who were treated with PCSK9 inhibitors either because of intolerance of statins or residual hypercholesterolaemia with evidence of cardiac allograft vasculopathy. We compared the data of patients prior to the start with these medications with their most recent dataset.

Resul

SUBMITTER: Kuhl M 

PROVIDER: S-EPMC6335020 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature