Plant-made E2 glycoprotein single-dose vaccine protects pigs against classical swine fever.

ABSTRACT: Classical Swine Fever Virus (CSFV) causes classical swine fever, a highly contagious hemorrhagic fever affecting both feral and domesticated pigs. Outbreaks of CSF in Europe, Asia, Africa and South America had significant adverse impacts on animal health, food security and the pig industry. The disease is generally contained by prevention of exposure through import restrictions (e.g. banning import of live pigs and pork products), localized vaccination programmes and culling of infected or at-risk animals, often at very high cost. Current CSFV-modified live virus vaccines are protective, but do not allow differentiation of infected from vaccinated animals (DIVA), a critical aspect of disease surveillance programmes. Alternatively, first-generation subunit vaccines using the viral protein E

SUBMITTER: Laughlin RC 

PROVIDER: S-EPMC6335066 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature