Smoking and Risk of Colorectal Cancer Sub-Classified by Tumor-Infiltrating T Cells.

ABSTRACT:

Background

Evidence indicates not only carcinogenic effect of cigarette smoking but also its immunosuppressive effect. We hypothesized that the association of smoking with colorectal cancer risk might be stronger for tumors with lower anti-tumor adaptive immune response.

Methods

During follow-up of 134 981 participants (3 490 851 person-years) in the Nurses' Health Study and Health Professionals Follow-up Study, we documented 729 rectal and colon cancer cases with available data on T-cell densities in tumor microenvironment. Using the duplication-method Cox regression model, we examined a differential association of smoking status with risk of colorectal carcinoma subclassified by densities of CD3+ cells, CD8+ cells, CD45RO (PTPRC)+ cells, or FOXP3+ cells. All statistical te

SUBMITTER: Hamada T 

PROVIDER: S-EPMC6335108 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature