Association Between Autologous Stem Cell Transplant and Survival Among Californians With Multiple Myeloma.

ABSTRACT:

Background

Autologous hematopoietic stem cell transplant (aHSCT) is an efficacious treatment for newly diagnosed multiple myeloma patients. However, as rapid advances have resulted in other highly efficacious and less intensive therapies, the role of aHSCT has been questioned.

Methods

We utilized population-based data to identify 13 494 newly diagnosed patients younger than age 80 years between 1998 and 2012. Patient characteristics of aHSCT and non-aHSCT groups were balanced using inverse probability weighting of a propensity score predicting aHSCT use. Multivariable models adjusted for baseline comorbidities, demographics, and socioeconomic status estimated the adjusted hazard ratio (aHR) and 95% confidence intervals (CIs) of death.

Results

Twenty point eight percen

SUBMITTER: Rosenberg AS 

PROVIDER: S-EPMC6335109 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature