Lactic Acid Accumulation in the Tumor Microenvironment Suppresses ¹⁸F-FDG Uptake.

ABSTRACT: The process by which tumor cells take up 2-[¹⁸F]fluoro-2-deoxy-D-glucose (FDG) is heterogeneous and influenced by a multitude of factors. In mouse tumor grafts, the core of the tumor often presents lower FDG uptake than the periphery. Whether this pattern is caused by the intrinsic avidity of individual cells for FDG, the density of viable cells in the tumor, or the perfusion of the radiotracer remains unknown. In this study, we used radioluminescence microscopy to measure FDG uptake in single cells isolated from the core and periphery of the tumor and found that differences in FDG uptake persist on the level of single cells. Single cells from the core of 4T1 and MDA-MB-231 tumors grafts took up 26% to 84% less FDG than those from the periphery. These differences were observed i

SUBMITTER: Turkcan S 

PROVIDER: S-EPMC6335173 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature