Prediction of Conversion From Amnestic Mild Cognitive Impairment to Alzheimer's Disease Based on the Brain Structural Connectome.

ABSTRACT: Background: Early prediction of disease progression in patients with amnestic mild cognitive impairment (aMCI) is important for early diagnosis and intervention of Alzheimer's disease (AD). Previous brain network studies have suggested topological disruptions of the brain connectome in aMCI patients. However, whether brain connectome markers at baseline can predict longitudinal conversion from aMCI to AD remains largely unknown. Methods: In this study, 52 patients with aMCI and 26 demographically matched healthy controls from a longitudinal cohort were evaluated. During 2 years of follow-up, 26 patients with aMCI were retrospectively classified as aMCI converters and 26 patients remained stable as aMCI non-converters based on whether they were subsequently diagnosed with AD.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC6335339 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature