Advances in genomic hepatocellular carcinoma research.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is the cancer with the second highest mortality in the world due to its late presentation and limited treatment options. As such, there is an urgent need to identify novel biomarkers for early diagnosis and to develop novel therapies. The availability of next-generation sequencing (NGS) data from tumors of liver cancer patients has provided us with invaluable resources to better understand HCC through the integration of data from different sources to facilitate the identification of promising biomarkers or therapeutic targets.

Findings

Here, we review key insights gleaned from more than 20 NGS studies of HCC tumor samples, comprising approximately 582 whole genomes and 1,211 whole exomes mainly from the East Asian population. Through

SUBMITTER: Huang W 

PROVIDER: S-EPMC6335342 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature