Modulation of Bladder Wall Micromotions Alters Intravesical Pressure Activity in the Isolated Bladder.

ABSTRACT: Micromotions are phasic contractions of the bladder wall. During urine storage, such phasic activity has little effect on intravesical pressure, however, changed motile activity may underlie urodynamic observations such as detrusor overactivity. The potential for bladder motility to affect pressure reflects a summation of the overall movements, comprising the initiation, propagation, and dissipation components of micromotions. In this study, the influence of initiation of micromotions was investigated using calcium activated chloride channel blocker niflumic acid, and the effect of propagation using blockers of gap junctions. The overall bladder tone was modulated using isoprenaline. Isolated tissue strips and whole bladder preparations from juvenile rats were used. 18β-glycyrrhetinic acid

SUBMITTER: Chakrabarty B 

PROVIDER: S-EPMC6335571 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature