Supporting data and methods for the multi-scale modelling of freeze-drying of microparticles in packed-beds.

ABSTRACT: A multi-scale approach can be used to simulate the drying behavior of microparticles in packed-bed. Data outcomes from discrete element method (DEM) and computational fluid dynamics (CFD) simulations can be used to estimate some relevant product characteristics, such as the porosity, tortuosity, voids in the bed and permeability which are required by the multi scale model. Data from DEM simulations are presented, with a particular focus on the influence of the model parameters, packing characteristics and inhomogeneities (wall effect and particles segregation); computational costs and scala bility are also considered. Data on the properties of packings as modeled at the macroscale are presented with regard to the thermal conductivity of gases in the Knudsen regime and effective properties

SUBMITTER: Capozzi LC 

PROVIDER: S-EPMC6335581 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature