Development of Morphologically Discrete PEG-PDLLA Nanotubes for Precision Nanomedicine.

ABSTRACT: Precise control over the morphological features of nanoparticles is an important requisite for their application in nanomedical research. Parameters such as size and shape have been identified as critical features for effective nanotherapeutic technologies due to their role in circulation, distribution, and internalization in vivo. Tubular PEG-PDLLA polymersomes (nanotubes) exhibit an interesting morphology with potential for immunotherapeutics, as the elongated shape can affect cell-particle interactions. Developing methodologies that permit control over the precise form of such nanotubes is important for their biomedical implementation due to the stringent physicochemical constraints for efficacious performance. Through careful control over the engineering process, we demonstrate the gen

SUBMITTER: Wauters AC 

PROVIDER: S-EPMC6335608 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature