A bio-inspired approach to ligand design: folding single-chain peptoids to chelate a multimetallic cluster.

ABSTRACT: Synthesis of biomimetic multimetallic clusters is sought after for applications such as efficient storage of solar energy and utilization of greenhouse gases. However, synthetic efforts are hampered by a dearth of ligands that are developed for multimetallic clusters due to current limitations in rational design and organic synthesis. Peptoids, a synthetic sequence-defined oligomer, enable a biomimetic strategy to rapidly synthesize and optimize large, multifunctional ligands by structural design and combinatorial screening. Here we discover peptoid oligomers (≤7 residues) that fold into a single conformation to provide unprecedented tetra- and hexadentate chelation by carboxylates to a [Co₄O₄] cubane cluster. The structures of peptoid-bound cubanes were determined by

SUBMITTER: Nguyen AI 

PROVIDER: S-EPMC6335634 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature