Inhibiting Bacterial Adhesion by Mechanically Modulated Microgel Coatings.

ABSTRACT: Bacterial infection is a severe problem especially when associated with biomedical applications. This study effectively demonstrates that poly- N-isopropylmethacrylamide based microgel coatings prevent bacterial adhesion. The coating preparation via a spraying approach proved to be simple and both cost and time efficient creating a homogeneous dense microgel monolayer. In particular, the influence of cross-linking density, microgel size, and coating thickness was investigated on the initial bacterial adhesion. Adhesion of Staphylococcus aureus ATCC 12600 was imaged using a parallel plate flow chamber setup, which gave insights in the number of the total bacteria adhering per unit area onto the surface and the initial bacterial deposition rates. All microgel coatings successfully yielded mo

SUBMITTER: Keskin D 

PROVIDER: S-EPMC6335679 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature