RiboTag translatomic profiling of Drosophila oenocytes under aging and induced oxidative stress.

ABSTRACT:

Background

Aging is accompanied with loss of tissue homeostasis and accumulation of cellular damages. As one of the important metabolic centers, liver shows age-related dysregulation of lipid metabolism, impaired detoxification pathway, increased inflammation and oxidative stress response. However, the mechanisms for these age-related changes still remain unclear. In the fruit fly, Drosophila melanogaster, liver-like functions are controlled by two distinct tissues, fat body and oenocytes. Compared to fat body, little is known about how oenocytes age and what are their roles in aging regulation. To characterize age- and stress-regulated gene expression in oenocytes, we performed cell-type-specific ribosome profiling (RiboTag) to examine the impacts of aging and oxidative stress on

SUBMITTER: Huang K 

PROVIDER: S-EPMC6335716 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature