A Proposed Mechanism for Spontaneous Transitions between Interictal and Ictal Activity.

ABSTRACT: Epileptic networks are characterized by two outputs: brief interictal spikes and rarer, more prolonged seizures. Although either output state is readily modeled in silico and induced experimentally, the transition mechanisms are unknown, in part because no models exhibit both output states spontaneously. In silico small-world neural networks were built using single-compartment neurons whose physiological parameters were derived from dual whole-cell recordings of pyramidal cells in organotypic hippocampal slice cultures that were generating spontaneous seizure-like activity. In silico, neurons were connected by abundant local synapses and rare long-distance synapses. Activity-dependent synaptic depression and gradual recovery delimited synchronous activity. Full synapti

SUBMITTER: Jacob T 

PROVIDER: S-EPMC6335741 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature