The potential of visible blue light (405 nm) as a novel decontamination strategy for carbapenemase-producing enterobacteriaceae (CPE).

ABSTRACT:

Background

Carbapenemase-producing Enterobacteriaceae (CPE) pose a considerable threat to modern medicine. New treatment options and methods to limit spread need to be investigated. Blue light (BL) is intrinsically antimicrobial, and we have previously demonstrated significant antimicrobial effects on biofilms of a panel of isolates, including two CPEs.This study was performed to assess the antibacterial activity of 405 nm BL against a panel of CPE isolates (four encoding bla _NDM, three bla _KPC, two bla _OXA-48, and three encoding both NDM and OXA-48 carbapenemases).

Methods

In vitro experiments were conducted on 72 h old biofilms of CPEs which were exposed to 60 mW/cm² of BL. Changes to biofilm seeding w

SUBMITTER: Halstead FD 

PROVIDER: S-EPMC6335786 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature