Identification of young adults at risk of an accelerated loss of kidney function in an area affected by Mesoamerican nephropathy.

ABSTRACT:

Background

After two-years of follow-up of 263 apparently healthy 18- to 30-year-old men in communities affected by Mesoamerican nephropathy (MeN), we identified three distinct case groups: a subgroup with (i) established renal dysfunction (case-group 1); individuals with (ii) a rapid decline in kidney function (case-group 2); and individuals with (iii) stable kidney function (non-cases). This paper investigates whether local tests are potentially useful for the timely identification of these case groups.

Methods

Creatinine levels were measured in local laboratories every six months for two years. Aliquots were sent to a centralized laboratory for measurements of cystatin C and creatinine levels. We investigated agreement between the locally and centrally measured creatinine

SUBMITTER: Gonzalez-Quiroz M 

PROVIDER: S-EPMC6335797 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature