Imaging Mass Spectrometry and Proteome Analysis of Marek's Disease Virus-Induced Tumors.

ABSTRACT: The highly oncogenic alphaherpesvirus Marek's disease virus (MDV) causes immense economic losses in the poultry industry. MDV induces a variety of symptoms in infected chickens, including neurological disorders and immunosuppression. Most notably, MDV induces transformation of lymphocytes, leading to T cell lymphomas in visceral organs with a mortality of up to 100%. While several factors involved in MDV tumorigenesis have been identified, the transformation process and tumor composition remain poorly understood. Here we developed an imaging mass spectrometry (IMS) approach that allows sensitive visualization of MDV-induced lymphoma with a specific mass profile and precise differentiation from the surrounding tissue. To identify potential tumor markers in tumors derived from a very virulen

SUBMITTER: Pauker VI 

PROVIDER: S-EPMC6336081 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature