Synthesis and potential antineoplastic activity of dehydroabietylamine imidazole derivatives.

ABSTRACT: To seek more efficient and lower toxicity anticancer compounds, several imidazole combining dehydroabietylamine derivatives including organic salts (L ¹ -L ² ) and amides (L ³ -L ⁵ ) were synthesized. Their antineoplastic activity against HeLa (cervix), MCF-7 (breast), A549 (lung) and HepG2 (liver) cells and HUVECs (umbilical vein, normal cells) in vitro were evaluated by MTT assay. The results unequivocally showed that nearly all compounds had better antineoplastic activity and lower toxicity than dehydroabietylamine (L ⁰ ). For MCF-7 cells, L ² (0.75 μM) and L ⁵ (2.17 μM) had higher anti-MCF-7 activity than <

SUBMITTER: Zhao F 

PROVIDER: S-EPMC6336084 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature