Chikungunya as a paradigm for emerging viral diseases: Evaluating disease impact and hurdles to vaccine development.

ABSTRACT: Chikungunya fever (CHIKF) is an emerging infectious disease caused by an alphavirus transmitted by Aedes spp. mosquitoes. Because mosquito control programs are not highly efficient for outbreak containment, vaccines are essential to reduce the burden of disease. Although no licensed vaccine against CHIKF is yet available, many highly promising candidates are undergoing preclinical studies, and a few of them have been tested in human trials of phase 1 or 2. Here, we review recent findings regarding the need for a CHIKF vaccine and provide an update on vaccines nearing or having entered clinical trials. We also address needs to tackle bottlenecks to vaccine development-including scientific and financial barriers-and to accelerate the development of vaccines; several actions should be taken:

SUBMITTER: Rezza G 

PROVIDER: S-EPMC6336248 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature