Renal function and risk factors for renal disease for patients receiving HIV pre-exposure prophylaxis at an inner metropolitan health service.

ABSTRACT:

Background

Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) significantly reduces the risk of HIV acquisition. TDF is a known nephrotoxin however, renal dysfunction from TDF is mostly reversible following discontinuation.

Aims

To describe the renal function, risk factors for renal disease and associated clinical testing practices in a cohort of PrEP patients.

Methods

A retrospective review was conducted of all PrEP patients commenced on TDF/FTC at an inner metropolitan sexual health clinic in Sydney, Australia between April 2016 and July 2017, with follow-up data obtained at 3-monthly intervals until 18 months.

Results

525 patients met inclusion criteria. Patients were almost exclusively male and median age was 34 years

SUBMITTER: Drak D 

PROVIDER: S-EPMC6336260 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature