Reproductive history and risk of nasopharyngeal carcinoma: A population-based case-control study in southern China.

ABSTRACT:

Objects

Nasopharyngeal carcinoma (NPC) incidence exhibits a remarkable sex disparity, with higher risk among males. Whether this pattern can be partly explained by female reproductive history is unclear.

Methods

A population-based case-control study of NPC was conducted in southern China between 2010 and 2014, including 674 histopathologically verified female NPC cases and 690 female controls randomly selected from population-based registries. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression after adjusting for potential confounders.

Results

Women who had 3, 4, or ≥5 pregnancies compared with 2 pregnancies were at significantly increased risk for NPC (ORs 1.56, 1.45 and 1.88, respectively). History of deliveries was similar

SUBMITTER: Feng RM 

PROVIDER: S-EPMC6336493 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature