Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials.

ABSTRACT:

Objective

Studies of dehydroepiandrosterone (DHEA) therapy in older adults suggest sex-specific effects on bone mineral density (BMD) and body composition, but the ability of a single study to reach this conclusion was limited. We evaluated the effects of DHEA on sex hormones, BMD, fat mass and fat-free mass in older women and men enrolled in four similar clinical trials.

Design

Pooled analyses of data from four double-blinded, randomized controlled trials.

Participants

Women (n = 295) and men (n = 290) aged 55 years or older who took DHEA or placebo tablet daily for 12 months.

Measurements

Twelve-month changes in BMD, fat mass, fat-free mass and serum DHEA sulphate (DHEAS), (17)estradiol, testosterone and insulin-like growth factor-1 (IGF-1).

Results

Wo

SUBMITTER: Jankowski CM 

PROVIDER: S-EPMC6336516 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature