High Completion Rate for 12 Weekly Doses of Isoniazid and Rifapentine as Treatment for Latent Mycobacterium tuberculosis Infection in the Federal Bureau of Prisons.

ABSTRACT:

Context

Correctional facilities provide unique opportunities to diagnose and treat persons with latent tuberculosis infection (LTBI). Studies have shown that 12 weekly doses of isoniazid and rifapentine (INH-RPT) to treat LTBI resulted in high completion rates with good tolerability.

Objective

To evaluate completion rates and clinical signs or reported symptoms associated with discontinuation of 12 weekly doses of INH-RPT for LTBI treatment.

Setting/participants

During July 2012 to February 2015, 7 Federal Bureau of Prisons facilities participated in an assessment of 12 weekly doses of INH-RPT for LTBI treatment among 463 inmates.

Main outcome measures

Fisher exact test was used to assess the associations between patient sociodemographic characteristics and cli

SUBMITTER: Schmit KM 

PROVIDER: S-EPMC6336524 | biostudies-literature | 2019 Mar/Apr

REPOSITORIES: biostudies-literature