Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings.

ABSTRACT: Older adults suffer from weakened and delayed bone healing due to age-related alterations in bone cells and in the immune system. Given the interaction between the immune system and skeletal cells, therapies that address deficiencies in both the skeletal and the immune system are required to effectively treat bone injuries of older patients. The sequence of macrophage activation observed in healthy tissue repair involves a transition from a pro-inflammatory state followed by a pro-reparative state. In older patients, inflammation is slower to resolve and impedes healing. The goal of this study was to design a novel drug delivery system for temporal guidance of the polarization of macrophages using bone grafting materials. A biomimetic calcium phosphate coating (bCaP) physically and tempora

SUBMITTER: Alhamdi JR 

PROVIDER: S-EPMC6336526 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature