Combined linkage and association analysis identifies rare and low frequency variants for blood pressure at 1q31.

ABSTRACT: High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD) and is more prevalent in African Americans as compared to other US groups. Although large, population-based genome-wide association studies (GWAS) have identified over 300 common polymorphisms modulating inter-individual BP variation, largely in European ancestry subjects, most of them do not localize to regions previously identified through family-based linkage studies. This discrepancy has remained unexplained despite the statistical power differences between current GWAS and prior linkage studies. To address this issue, we performed genome-wide linkage analysis of BP traits in African-American families from the Family Blood Pressure Program (FBPP) and genotyped on the Illumina Human Exome BeadChip v1.1. We

SUBMITTER: Wang H 

PROVIDER: S-EPMC6336803 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature