In-vivo correlations between skin metabolic oscillations and vasomotion in wild-type mice and in a model of oxidative stress.

ABSTRACT: Arterioles in the cutaneous microcirculation frequently display an oscillatory phenomenon defined vasomotion, consistent with periodic diameter variations in the micro-vessels associated with particular physiological or abnormal conditions. The cellular mechanisms underlying vasomotion and its physiological role have not been completely elucidated. Various mechanisms were demonstrated, based on cell Ca²⁺ oscillations determined by the activity of channels in the plasma membrane or sarcoplasmic reticulum of vascular cells. However, the possible engagement in vasomotion of cell metabolic oscillations of mitochondrial or glycolytic origin has been poorly explored. Metabolic oscillations associated with the production of ATP energy were previously described in cells, while limited s

SUBMITTER: Smirni S 

PROVIDER: S-EPMC6336806 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature