Genetic associations with suicide attempt severity and genetic overlap with major depression.

ABSTRACT: In 2015, ~800,000 people died by suicide worldwide. For every death by suicide there are as many as 25 suicide attempts, which can result in serious injury even when not fatal. Despite this large impact on morbidity and mortality, the genetic influences on suicide attempt are poorly understood. We performed a genome-wide association study (GWAS) of severity of suicide attempts to investigate genetic influences. A discovery GWAS was performed in Yale-Penn sample cohorts of European Americans (EAs, n = 2,439) and African Americans (AAs, n = 3,881). We found one genome-wide significant (GWS) signal in EAs near the gene LDHB (rs1677091, p = 1.07 × 10^-8) and three GWS associations in AAs: ARNTL2 on chromosome 12 (rs683813, p = 2.07 × 10^-8), FAH on chromosome 15 (rs72740082

SUBMITTER: Levey DF 

PROVIDER: S-EPMC6336846 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature