Predictors of objective cognitive impairment and subjective cognitive complaints in patients with Fabry disease.

ABSTRACT: This study investigates the relationship between objective cognitive impairment (OCI), subjective cognitive complaints and depressive symptoms in men and women with classical and non-classical Fabry disease (FD). Cognitive functioning was assessed using a neuropsychological test battery, subjective cognitive complaints using a structured interview and depressive symptoms using a depression scale (CESD). Eighty-one patients were included (mean age 44.5 ± 14.3, 35% men, 74% classical). Subjective cognitive complaints were reported by 64% of all patients. OCI was present in thirteen patients (16%), predominantly in men with classical FD. Thirty-one patients (38%) had a high score (≥16) on the CESD scale. Male sex (OR, 6.8; 95%CI, 1.6-39.8; p = 1.6 * 10^-2) and stroke (OR, 6.4; 95% C

SUBMITTER: Korver S 

PROVIDER: S-EPMC6336934 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature