Associations between the gut microbiota and host responses to high altitude.

ABSTRACT: Hypobaric hypoxia and dietary protein and fat intakes have been independently associated with an altered gastrointestinal (GI) environment and gut microbiota, but little is known regarding host-gut microbiota interactions at high altitude (HA) and the impact of diet macronutrient composition. This study aimed to determine the effect of dietary protein:fat ratio manipulation on the gut microbiota and GI barrier function during weight loss at high altitude (HA) and to identify associations between the gut microbiota and host responses to HA. Following sea-level (SL) testing, 17 healthy males were transported to HA (4,300 m) and randomly assigned to consume provided standard protein (SP; 1.1 g·kg^-1·day^-1, 39% fat) or higher protein (HP; 2.1 g·kg^-1·day^-1</

SUBMITTER: Karl JP 

PROVIDER: S-EPMC6336946 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature