Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease.

ABSTRACT: In polycystic kidney disease (PKD), persistent activation of cell proliferation and matrix production contributes to cyst growth and fibrosis, leading to progressive deterioration of renal function. Previously, we showed that periostin, a matricellular protein involved in tissue repair, is overexpressed by cystic epithelial cells of PKD kidneys. Periostin binds α_Vβ₃-integrins and activates integrin-linked kinase (ILK), leading to Akt/mammalian target of rapamycin (mTOR)-mediated proliferation of human PKD cells. By contrast, periostin does not stimulate the proliferation of normal human kidney cells. This difference in the response to periostin is due to elevated expression of α_Vβ₃-integrins by cystic cells. To determine whether periostin acceler

SUBMITTER: Raman A 

PROVIDER: S-EPMC6336984 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature