Role of (pro)renin receptor in albumin overload-induced nephropathy in rats.

ABSTRACT: Proteinuria is not only a common feature of chronic kidney diseases (CKD) but also an independent risk factor promoting CKD progression to end-stage renal failure. However, the underlying molecular mechanisms for protein overload-induced renal injury remain elusive. The present study examined the role of (pro)renin receptor (PRR) in pathogenesis of albumin overload (AO)-induced nephropathy and activation of the intrarenal renin-angiotensin system (RAS) in rats. Wistar rats underwent unilateral nephrectomy and were treated for 7 wk with vehicle, bovine serum albumin (5 g·kg^-1·day^-1 via a single ip injection), alone or in conjunction with the PRR decoy inhibitor PRO20 (500 μg·kg^-1·day^-1 via 3 sc injections). The AO rat model exhibited severe protei

SUBMITTER: Fang H 

PROVIDER: S-EPMC6336996 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature