In Vitro Cytotoxicity Evaluation of the Magneli Phase Titanium Suboxides (TixO2x-1) on A549 Human Lung Cells.

ABSTRACT: The use of titanium suboxides, known as Magnéli phase TiOx, is expected to increase in the near future due to their desirable properties. In order to use Magnéli phase TiOx nanoparticles safely, it is necessary to know how nanoparticles interact with biological systems. In this study, the cytotoxicity of three different Magnéli TiOx nanoparticles was evaluated using human lung A549 cells and the results were compared with hazard data on two different TiO₂ nanoparticles whose biological interactions have already been extensively studied. After A549 cells were exposed to nanoparticles, the metabolic activity was measured by the Resazurin assay, the amount of cellular proteins was measured by the Coomassie Blue assay, and lysosomal integrity was measured by the Neutral Red Uptake assay. In or

SUBMITTER: Kononenko V 

PROVIDER: S-EPMC6337184 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature