Comparative Study of the Molecular Basis of Pathogenicity of M. bovis Strains in a Mouse Model.

ABSTRACT: It is widely accepted that different strains of Mycobacterium tuberculosis have variable degrees of pathogenicity and induce different immune responses in infected hosts. Similarly, different strains of Mycobacterium bovis have been identified but there is a lack of information regarding the degree of pathogenicity of these strains and their ability to provoke host immune responses. Therefore, in the current study, we used a mouse model to evaluate various factors involved in the severity of disease progression and the induction of immune responses by two strains of M. bovis isolated from cattle. Mice were infected with both strains of M. bovis at different colony-forming unit (CFU) via inhalation. Gross and histological findings revealed more severe lesions in

SUBMITTER: Cheng G 

PROVIDER: S-EPMC6337294 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature