Increasing Uptake of Silica Nanoparticles with Electroporation: From Cellular Characterization to Potential Applications.

ABSTRACT: In the fields of biology and medicine, nanoproducts such as nanoparticles (NPs) are specifically interesting as theranostic tools, since they offer the double capacity to locally deliver active drugs and to image exactly where the product is delivered. Among the many described possibilities, silica nanoparticles (SiNPs) represent a good choice because of their ease of synthesis, the possibility of their vast functionalization, and their good biocompatibility. However, SiNPs' passive cell internalization by endocytosis only distributes NPs into the cell cytoplasm and is unable to target the nucleus if SiNPs are larger than a few nanometers. In this study, we demonstrate that the cell penetration of SiNPs of 28⁻30 nm in diameter can be strongly enhanced using a physical method, called electr

SUBMITTER: Phonesouk E 

PROVIDER: S-EPMC6337455 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature