Fascin-1 enhances experimental osteosarcoma tumor formation and metastasis and is related to poor patient outcome.

ABSTRACT:

Background

Fascin-1, a prominent actin-bundling protein, is found to be upregulated in several human carcinomas. While it is accepted that Fascin-1 expression correlates with poor clinical outcome and decreased survival in various carcinomas, its role in sarcoma such as osteosarcoma (OS) remains unknown. In the present study, we evaluated the prognostic value and biological relevance of Fascin-1 in OS.

Methods

The correlation between Fascin-1 expression and the outcome of OS patients was determined by immunohistochemistry analysis of Fascin-1 expression in a tissue microarray of OS tissue specimens collected during primary tumor resection. To examine the effect of Fascin-1, shRNA and overexpression technology to alter Fascin-1 levels in OS cells were used in cellular assays

SUBMITTER: Arlt MJ 

PROVIDER: S-EPMC6337773 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature