The evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis.

ABSTRACT:

Background

The Notch signaling pathway governs the specification of different cell types in flies, nematodes and vertebrates alike. Principal components of the pathway that activate Notch target genes are highly conserved throughout the animal kingdom. Despite the impact on development and disease, repression mechanisms are less well studied. Repressors are known from arthropods and vertebrates that differ strikingly by mode of action: whereas Drosophila Hairless assembles repressor complexes with CSL transcription factors, competition between activator and repressors occurs in vertebrates (for example SHARP/MINT and KyoT2). This divergence raises questions on the evolution: Are there common ancestors throughout the animal kingdom?

Results

Available genome databases r

SUBMITTER: Maier D 

PROVIDER: S-EPMC6337844 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature