Antipsychotic Drug Responsiveness and Dopamine Receptor Signaling; Old Players and New Prospects.

ABSTRACT: Antipsychotic drugs targeting dopamine neurotransmission are still the principal mean of therapeutic intervention for schizophrenia. However, about one third of people do not respond to dopaminergic antipsychotics. Genome wide association studies (GWAS), have shown that multiple genetic factors play a role in schizophrenia pathophysiology. Most of these schizophrenia risk variants are not related to dopamine or antipsychotic drugs mechanism of action. Genetic factors have also been implicated in defining response to antipsychotic medication. In contrast to disease risk, variation of genes coding for molecular targets of antipsychotics have been associated with treatment response. Among genes implicated, those involved in dopamine signaling mediated by D2-class dopamine receptor, including

SUBMITTER: Rampino A 

PROVIDER: S-EPMC6338030 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature