¹⁸F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images.

ABSTRACT:

Background

Microcalcifications in atherosclerotic plaques are destabilizing, predict adverse cardiovascular events, and are associated with increased morbidity and mortality.¹⁸F-fluoride positron emission tomography (PET)/computed tomography (CT) imaging has demonstrated promise as a useful clinical diagnostic tool in identifying high-risk plaques; however, there is confusion as to the underlying mechanism of signal amplification seen in PET-positive, CT-negative image regions. This study tested the hypothesis that ¹⁸F-fluoride PET/CT can identify early microcalcifications.

Methods

¹⁸F-fluoride signal amplification derived from microcalcifications was validated against near-infrared fluorescence molecular imaging and histology using an in vit

SUBMITTER: Creager MD 

PROVIDER: S-EPMC6338081 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature