Typing complex meningococcal vaccines to understand diversity and population structure of key vaccine antigens.

ABSTRACT: Background: Protein-conjugate capsular polysaccharide vaccines can potentially control invasive meningococcal disease (IMD) caused by five (A, C, W, X, Y) of the six IMD-associated serogroups.  Concerns raised by immunological similarity of the serogroup B capsule to human neural cell carbohydrates, meant that 'serogroup B substitute' vaccines target more variable subcapsular protein antigens.  A successful approach using outer membrane vesicles (OMVs) as major vaccine components had limited strain coverage. In 4CMenB (Bexsero ^®), recombinant proteins have been added to ameliorate this problem.  Methods: Scalable, portable, genomic techniques were used to investigate the Bexsero ^® OMV protein diversity in meningococcal populations. Shotgun proteomics ide

SUBMITTER: Rodrigues CMC 

PROVIDER: S-EPMC6338130 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature