Basal forebrain cholinergic system volume is associated with general cognitive ability in the elderly.

ABSTRACT:

Objective

At the present, it is unclear whether association of basal forebrain cholinergic system (BFCS) volume with cognitive performance exists in healthy as well as in cognitively impaired elderly subjects. Whereas one small study reported an association of BFCS volume with general cognitive ability 'g' in healthy ageing, effects on specific cognitive domains have only been found in subjects with cognitive decline. Here we aim to clarify whether an association of BFCS volume and 'g' is present in a larger sample of elderly subjects without obvious symptoms of dementia and whether similar associations can also be observed in specific cognitive domains.

Methods

282 pre-surgical patients from the BioCog study (aged 72.7 ± 4.9 years with a range of 65-87 years, 110 women) wit

SUBMITTER: Lammers F 

PROVIDER: S-EPMC6338214 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature