Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations.

ABSTRACT: Recent identification of a mammary gland-specific microbiome led to studies investigating bacteria populations in breast cancer. Malignant breast tumors have lower Lactobacillus abundance compared with benign lesions, implicating Lactobacillus as a negative regulator of breast cancer. Diet is a main determinant of gut microbial diversity. Whether diet affects breast microbiome populations is unknown. In a non-human primate model, we found that consumption of a Western or Mediterranean diet modulated mammary gland microbiota and metabolite profiles. Mediterranean diet consumption led to increased mammary gland Lactobacillus abundance compared with Western diet-fed monkeys. Moreover, mammary glands from Mediterranean diet-fed monkeys had higher levels of bile acid metabolites and increased b

SUBMITTER: Shively CA 

PROVIDER: S-EPMC6338220 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature