Arsenic, tobacco smoke, and occupation: associations of multiple agents with lung and bladder cancer.

ABSTRACT:

Background

Millions of people worldwide are exposed to arsenic in drinking water, and many are likely coexposed to other agents that could substantially increase their risks of arsenic-related cancer.

Methods

We performed a case-control study of multiple chemical exposures in 538 lung and bladder cancer cases and 640 controls in northern Chile, an area with formerly high drinking water arsenic concentrations. Detailed information was collected on lifetime arsenic exposure, smoking, secondhand smoke, and other known or suspected carcinogens, including asbestos, silica, and wood dust.

Results

Very high lung and bladder cancer odds ratios (ORs), and evidence of greater than additive effects, were seen in people exposed to arsenic concentrations >335 µg/L and who were tob

SUBMITTER: Ferreccio C 

PROVIDER: S-EPMC6338230 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature