Identification, pathophysiology, and clinical implications of primary insulin hypersecretion in nondiabetic adults and adolescents.

ABSTRACT:

Background

Excessive insulin secretion may lead to glucose dysregulation. Our aim was to identify primary (independent of insulin resistance) insulin hypersecretion in subjects with normal glucose tolerance and its role in the progression of dysglycemia.

Methods

In 1,168 adults, insulin secretion rate (ISR) and β cell function were estimated by C-peptide modeling during an oral glucose tolerance test (OGTT) and an i.v. glucose tolerance test. Whole-body insulin sensitivity was measured by a hyperinsulinemic-euglycemic clamp. After regressing ISR on insulin sensitivity, subjects in the upper tertile of the distribution of residuals were defined as primary hypersecretors. This approach was applied to a biethnic cohort of 182 obese adolescents, who received an OGTT, a hyperglyc

SUBMITTER: Trico D 

PROVIDER: S-EPMC6338316 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature