Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells.

ABSTRACT: High morbidity and mortality are common traits of malignant tumours and identification of the cells responsible is a focus of on-going research. Many studies are now reporting the use of antibodies specific to Clusters of Differentiation (CD) cell surface antigens to identify tumour-initiating cell (TIC) populations in neural tumours. Medulloblastoma is one of the most common malignant brain tumours in children and despite a considerable amount of research investigating this tumour, the identity of the TICs, and the means by which such cells can be targeted remain largely unknown. Current prognostication and stratification of medulloblastoma using clinical factors, histology and genetic profiling have classified this tumour into four main subgroups: WNT, Sonic hedgehog (SHH), Group 3 and G

SUBMITTER: Robson JP 

PROVIDER: S-EPMC6338368 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature