Symbiont-derived sphingolipids regulate inflammatory responses in rainbow trout (Oncorhynchus mykiss).

ABSTRACT: Farmed fish live in association with diverse bacterial communities that produce wide arrays of metabolites. In rainbow trout, the skin and the gills are colonized by Flectobacillus major, a bacterium known to produce sphingolipids (SLs). The goal of this study is to evaluate the ability of F. major SLs to regulate rainbow trout inflammatory responses. F. major SLs were delivered by themselves or in combination with Freund's Complete Adjuvant (FCA), an oil-based adjuvant known to cause severe abdominal inflammation when injected to fish. Trout injected with SL + FCA showed decreased severity of FCA toxic effects including necrosis, granuloma formation and presence of oil droplets. However, inclusion of SLs in the FCA preparation did not decrease infiltration of immune c

SUBMITTER: Sanchez M 

PROVIDER: S-EPMC6338430 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature