Opening up about Tissue Transglutaminase: When Conformation Matters More than Enzymatic Activity.

ABSTRACT: Tissue transglutaminase (tTG), also referred to as type 2 transglutaminase or Gα_h, can bind and hydrolyze GTP, as well as function as a protein crosslinking enzyme. tTG is widely expressed and can be detected both inside cells and in the extracellular space. In contrast to many enzymes, the active and inactive conformations of tTG are markedly different. The catalytically inactive form of tTG adopts a compact "closed-state" conformation, while the catalytically active form of the protein adopts an elongated "open-state" conformation. tTG has long been appreciated as an important player in numerous diseases, including celiac disease, neuronal degenerative diseases, and cancer, and its roles in these diseases often depend as much upon its conformation as its catalytic activity. Wh

SUBMITTER: Katt WP 

PROVIDER: S-EPMC6338449 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature