Targeted Delivery of Antigen to Activated CD169⁺ Macrophages Induces Bias for Expansion of CD8⁺ T Cells.

ABSTRACT: Macrophages (MØs) expressing the endocytic sialic acid-binding immunoglobulin-like lectin 1 (siglec-1, CD169, sialoadhesin) are known to be adept at antigen capture-primarily due to their strategic location within lymphatic tissues. Antigen concentrated in these cells can be harnessed to induce potent anti-tumor/anti-pathogen cytotoxic (CD8⁺) T cell responses. Here, we describe a chemical platform that exploits the CD169-mediated antigen capture pathway for biased priming of antigen-specific CD4⁺ or CD8⁺ T cells in vivo. In the absence of a toll-like receptor (TLR) agonist, antigen delivery through CD169 produced robust CD4⁺ T cell priming only. However, simultaneous treatment with targeted antigen and a TLR7 agonist induced CD8⁺ T cel

SUBMITTER: Edgar LJ 

PROVIDER: S-EPMC6338492 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature