Sensorimotor network segregation declines with age and is linked to GABA and to sensorimotor performance.

ABSTRACT: Aging is typically associated with declines in sensorimotor performance. Previous studies have linked some age-related behavioral declines to reductions in network segregation. For example, compared to young adults, older adults typically exhibit weaker functional connectivity within the same functional network but stronger functional connectivity between different networks. Based on previous animal studies, we hypothesized that such reductions of network segregation are linked to age-related reductions in the brain's major inhibitory transmitter, gamma aminobutyric acid (GABA). To investigate this hypothesis, we conducted graph theoretical analyses of resting state functional MRI data to measure sensorimotor network segregation in both young and old adults. We also used magnetic resonance

SUBMITTER: Cassady K 

PROVIDER: S-EPMC6338503 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature